Theme 2: Cellular and Organismal Responses

Cellular and Organismal Responses research examines the impact of nanomaterials on organisms with respect to nanomaterials bioavailability, developmental impacts and toxicity. Bioavailability and toxicity testing serve a vital screening function, allowing us to examine a broad range of nanomaterials and build a database for calibrating and validating structure-activity models. Theme 2 studies 1) develop assays to rapidly screen for nanomaterial properties that may invoke toxic responses, and 2) identifies mechanisms acting at the molecular scale that explain the observed organismal and ecosystem responses that, taken in conjunction with activities in Theme 1, lay the groundwork for interpreting the ecosystem responses in Theme 3.

Selected Publicaitons

N. K. Geitner, Marinakos, S. M. , Guo, C. , O’Brien, N. , and Wiesner, M. R. , Nanoparticle Surface Affinity as a Predictor of Trophic Transfer, Environmental Science & Technology, vol. 50, no. 13, pp. 6663 - 6669, 2016.
C. O. Hendren, Lowry, G. V. , Unrine, J. M. , and Wiesner, M. R. , A functional assay-based strategy for nanomaterial risk forecasting, Science of The Total Environment, 2015.
E. P. Vejerano, Ma, Y. , Holder, A. L. , Pruden, A. , Elankumaran, S. , and Marr, L. C. , Toxicity of particulate matter from incineration of nanowaste, Environ. Sci.: Nano, 2015.
D. L. Starnes, Unrine, J. M. , Starnes, C. P. , Collin, B. E. , Oostveen, E. K. , Ma, R. , Lowry, G. V. , Bertsch, P. M. , and Tsyusko, O. V. , Impact of sulfidation on the bioavailability and toxicity of silver nanoparticles to Caenorhabditis elegans, Environmental Pollution, vol. 196, pp. 239 - 246, 2015.
S. - R. Chae, Hunt, D. E. , Ikuma, K. , Yang, S. , Cho, J. , Gunsch, C. K. , Liu, J. , and Wiesner, M. R. , Aging of fullerene C60 nanoparticle suspensions in the presence of microbes, Water Research, vol. 65, pp. 282 - 289, 2014.
A. J. Bone, Matson, C. W. , Colman, B. P. , Yang, X. , Meyer, J. N. , and Di Giulio, R. T. , Silver nanoparticle toxicity to Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: A comparison of mesocosm, microcosm and conventional laboratory studies, Environmental Toxicology and Chemistry, 2014.
Y. Ma, Elankumaran, S. , Marr, L. C. , Vejerano, E. P. , and Pruden, A. , Toxicity of engineered nanomaterials and their transformation products following wastewater treatment on A549 human lung epithelial cells, Toxicology Reports, vol. 1, pp. 871 - 876, 2014.
M. Auffan, Matson, C. W. , Rose, J. , Arnold, M. , Proux, O. , Fayard, B. , Liu, W. , Chaurand, P. , Wiesner, M. R. , Bottero, J. - Y. , and Di Giulio, R. T. , Salinity-dependent silver nanoparticle uptake and transformation by Atlantic killifish (Fundulus heteroclitus) embryos, Nanotoxicology, vol. 8, pp. 167-176, 2014.
M. Auffan, Tella, M. , Santaella, C. , Brousset, L. , Paillès, C. , Barakat, M. , Espinasse, B. , Artells, E. , Issartel, J. , Masion, A. , Rose, J. , Wiesner, M. R. , Achouak, W. , Thiéry, A. , and Bottero, J. - Y. , An adaptable mesocosm platform for performing integrated assessments of nanomaterial risk in complex environmental systems, Scientific Reports, vol. 4, 2014.
J. Choi, Tsyusko, O. V. , Unrine, J. M. , Chatterjee, N. , Ahn, J. - M. , Yang, X. , Thornton, L. B. , Ryde, I. T. , Starnes, D. , and Meyer, J. N. , A micro-sized model for the in vivo study of nanoparticle toxicity: what has Caenorhabditis elegans taught us?, Environmental Chemistry, vol. 11, no. 3, p. 227, 2014.